Drug induced hepatitis adalah pdf

Druginduced liver injury dili, whether doserelated as with acetaminophen or idiosyncratic, is the most common cause of acute liver failure in the united states. Druginduced hepatitis involves inflammation of the liver, caused by medication. More than 900 drugs, toxins, and herbs have been reported to cause liver injury. If there is too much medicine in your blood for your liver to break down, your liver can become badly damaged. Druginduced hepatitis is similar to acute viral hepatitis but parenchymal destruction tends to be more extensive. The incidence of ranitidineassociated acute hepatitis has been estimated. Certain drugs can cause damage to the liver in a variety of ways. Out of the cohort of 3900 tuberculosis patients who were initiated on antitubercular therapy, 150 patients who developed druginduced liver injury due to short. Druginduced liver injury dili is common and nearly all classes of medications can cause liver disease. Hepatotoxicity caused by drugs used for therapeutic, recreational or nutritional purposes as well as drugs of abuse is a drug induced liver disease dild.

Liver often plays a critical role in the me tabolism of drugs and xenobiotics, leading to a. Desain studi adalah observasi analitik dengan case control. Idiosyncratic unpredictable druginduced liver injury is one of the most challenging liver. Depending on the duration of injury and the histological location of damage, druginduced liver injury dili is categorized as acute or chronic, and either as hepatitis, cholestatic, or a mixed pattern of injury. Pdf drug induced liver injury is a serious human health problems. Although some drugs present a narrow signature, others have a very broad signature.

The predominant clinical presentation is acute hepatitis andor cholestasis, although almost any. The liver helps to break down certain medicines in your blood. Druginduced hepatitis and the risk factors for liver injury in. Ppt lapsus tb dih drug induced hepatitis kiky martha. Transaminase elevation during the course of antitb therapy may in some instances actually represent coincidentally devel oped hepatitis a, b, or c 20, 21. Pdf hepatitis akibat obat anti tuberkulosis oat merupakan. Tuberkulosis milier dan hivaids dengan druginduced hepatitis. Approximately 75% of the idiosyncratic drug reactions result in liver transplantation or death.

Antituberculosis drug induced liver injury atli, obat anti. Idiosyncratic unpredictable druginduced liver injury is one of the most challenging liver disorders. Profil pasien tuberkulosis anak dengan antituberculosis drug induced hepatotoxicity. Because the liver is responsible for concentrating and metabolizing a majority of medications, it is a prime target for medicationinduced damage. A search was performed using the mayo clinic diagnostic medical index for aih patients and diaih patients identified over 10 years. Pdf the incidence of drug induced liver injury dili is about 1 to 10 among patients who receive therapeutic drug doses. Once the relevant drug has been identified, the patient needs to. Acute drug hepatitis with jaundice is life threatening 10% mortality hys law 3.

Various types of drug induced liver diseases are acutedose dependent hepatitis, liver cirrhosis, liver tumors etc. Druginduced hepatitis is diagnosed with a complete medical history and physical examination, specific laboratory blood tests, ultrasound and liver biopsy. A variety of clinical syndromes may be seen with dili, even with a single drug. Druginduced hepatitis is a redness and swelling inflammation of the liver that is caused by a harmful toxic amount of certain medicines. The risk of antituberculosis tb druginduced liver injury dili in patients with chronic viral hepatitis. The bulk of adverse hepatic drug reactions present with an acute hepatitis, cholestasis or mixed signature. Jurnal kedokteran brawijaya, vol 28, no 3 2015, pp. The most effective treatment for druginduced liver disease is the one thats also most obvious. Druginduced hepatotoxicity is a frequent cause of liver injury. Profil pasien tuberkulosis anak dengan antituberculosis drug. Insiden dan gambaran klinis hepatitis akibat obat anti. Drug induced liver injury dili is an adverse reaction to drugs or other xenobiotics that occurs either as a predictable event when an individual is. Pdf insiden dan gambaran klinis hepatitis akibat obat anti.

Pdf administration of drug induce liver injury to the. Druginduced hepatitis diagnosis stanford health care. Gejalagejala yang paling sering timbul adalah rasa mual dan muntah 48%. More than 900 drugs have been implicated in causing liver injury and it is the most common reason for a drug to be withdrawn from the market.